Hydration Fluid From OUTERSPACE!

December 15, 2009

theRightStuffA blog I thoroughly enjoy called the Cozy Beehive wrote a post last week about an electrolyte formula that NASA uses to hydrate it’s astronauts when returning to Earth.  It’s common for astronauts to return in a very dehydrated state because of the effects of weightlessness in space.  Leave it to NASA to spend 15 years  and squillions of dollars of development to create an isotonic electrolyte formula.

As the Cozy Beehive also uncovered, during NASA’s research they found that it increased cycling endurance in astronauts by 20% on ergometer tests.  I think the 20% is compared to drinking regular water (but all sports drinks claim to bolster the diet and increase endurance).  Of course this electrolyte formula has now been commercialized by a company called Wellness Brands and the product of interest is “The Right Stuff”.

Fellow Tipster named Mark Kelly has done some heavy investigation into this formula.   He tracked down the US patent document for this “Right Stuff” formula and worked out how to make it for a few cents per litre using ingredients you can buy at the supermarket.   Mark has a background in engineering and biological sciences and has worked as a winemaker and brewer for almost 25 years.  I think this qualifies him to speak with authority on this topic.

Thank you Mark for sharing your expertise with us to help us save money and go faster on the bike!

The formulation for the hydration fluid is revealed in US Patent 5447730.

The fluid has a sodium content equivalent to isotonic saline (3.6 g/l as Na), with half of the sodium present as common salt giving an NaCl concentration of 4.5 g/l.

The other half of the sodium content is present as sodium citrate, giving a concentration of 6.7 g/l. An easy way to make sodium citrate is by neutralising citric acid with sodium hydrogen carbonate (bicarb soda). To get 6.7 g/l sodium citrate, add 5 g/l citric acid plus 6.6 g/l bicarb soda.

One problem is that it tastes simply awful at this strength, like salty lemon juice without the sweetness. The easy answer is to sweeten it but you can’t add sugar because it will disturb the osmotic balance (this is the mistake that all the commercial Gatorade type fluids make). To maintain osmotic balance you need to use an artificial sweetener, I tried the aspartyl phenylalanine (Aspartame) based “Equal” and found that 2 tabs per litre was about right, your mileage may vary.

To make NASA’s rehydration fluid:

Easy method: Add 1½ teaspoons salt, 2½ teaspoons citric acid and 2¾ teaspoons bicarb soda to a bowl, slowly add a cup of warm water and stir until the bubbling stops and everything is dissolved. Add sweetener of choice. Make up to 2 litres with tap water. Sorry about the 2¾ but 2½ is not quite enough and 3 is too much. If you add too little bicarb the mixture will taste a bit sharp. If you add too much the residual will react with stomach acid and generate CO2 which may cause gastric discomfort (like taking an antacid).

More precise method: Measure 90 grams salt, 100 grams citric acid and 132 grams bicarb soda into a bowl. Slowly add 3 cups warm water and stir until the bubbling stops and everything is dissolved. Add sweetener of choice and make up to 1 litre with water. Store the concentrate in fridge and make 50 ml up to 1 litre with water as needed. Makes 20 litres total.

The purpose of the extra dilution steps is to reduce the carbonate concentration in the water. The purpose of adding the sweetener after cooling is that some sweeteners are heat labile. With some sweeteners you may get a slight cloudiness, this is due to the carrier compounds used in the sweetener. If this is a concern leave the solution to settle then decant the clear fluid off.

The cost depends on the source of the citric acid – in the wine industry we pay about $4 per kg for food grade citric but Safeway sees fit to charge $2.20 for 75 g (almost $30 per kg). If you can get the citric at a decent price the cost is under 15c per litre, even paying inflated supermarket prices for the ingredients the total cost is less than 30c per litre.

Don’t worry about the salt content of the tap water, it’s tiny in comparison: I measured my tap water at about 200ppm TDS which is less than 0.01% Na. Even Adelaide water at its worst is less than 0.03% according to the SA water authority.

The one question I had for Mark was this:

Q: The statement “One problem is that it tastes simply awful at this strength, like salty lemon juice without the sweetness. The easy answer is to sweeten it but you can’t add sugar because it will disturb the osmotic balance (this is the mistake that all the commercial Gatorade type fluids make).” Does that mean that you should avoid ingesting sugary foods while exercising as well so that you don’t disturb the balance of this fluid?  Or does your body treat it separately if you ingest it a reasonable time apart?

A: Yes, taking food at the same time as taking the drink will reduce its effect. To the best of my knowledge a 15 minute period is enough to absorb the majority of the fluid so optimal hydration would require a gap of that length between drinking and food intake.

  • Mark_Kelly
    As stated above, trying to combine rehydration and energy replacement in a single product compromises both functions. If you follow that argument, all commercial "energy drinks" are a waste of resources.

    Drink to rehydrate, eat to refuel, don't try to mix the two.
  • randomactsofcycling
    For me the best 'off the shelf' Sports Drink has always been Lucozade. Much lower in sugar than all the other 'ades' and more glucose.
    Gatorade, Staminade, Powerade....all just overpriced cordial and all the excess sugar just makes me thirstier (which I suppose is the point).
    Interestingly, all the Energy Gel makers recommend taking fluids when you down a Gel. I assume this is a a no-no with this formula?
    As one that has been a water only cyclist for several years, I'm going to give this a try. The science has been explained to me before I got hit with any marketing hype.
  • Crazy Canuck
    (this is the mistake that all the commercial Gatorade type fluids make).

    So based on this above statement, am I the only one that did not know Gatorade was a waste of time? Or am I just reading this wrong?
    If Gatorade is no good, which commercial ones out there are worth their salt?

    Cheers!
    Canuck
  • Callum
  • Nbob
    Wow- I'm impressed with David Belaga. I would have thought the typical response would have been a lawyers letter along the lines of " patent..blah blah ....trade secret...blah blah...cease and desist" even if they had no grounds to issue one .

    Just for being so cool I'm gonna score some "Right Stuff" and give it a try- ( that and the fact I can't even mix a passable martini let alone something that calls for measuring grams per liter)
  • Tim
    Great point. Embrace the market, don't fight it.

    He deserves uber points (wonder if he rocks Google Alerts?)
  • Mark_Kelly
    It is a US patent and doesn't appear to have any dependent international filings, so AFAIK there is no protection in Australia. By law you can't patent something and keep it secret - for your patent to be valid someone who is "skilled in the art" must be able to reproduce your invention.

    Tht asid, I wish David's business well. If his stuff was available here (and I wasn't broke and unemployed) even I would just buy it rather than make it myself.
  • Jeff
    This stuff sounds eerily like E-Load. If you wanted to get some calories with a real sweetener, couldn't you just decrease the salt concentration like Infinit does?
  • singletracking
    What about other salts? We 'need' more than sodium to 'rehydrate' don't we? magnesium, potassium, calcium etc...
  • Mark_Kelly
    You carry your own energy source (your liver) but you need an external water source.

    Consider an athlete with an aerobic power output of say 300 watts. At a metabolic conversion efficiency of say 25% this requires a fuel burn of 1.2kJ per second or about 4000 kJ per hour. Glucose is a carbohydrate and gives 16 kJ per gram so this is a total fuel burn of 250 grams of glucose per hour.

    A drink supplement of 20 g CH2O is thus less than 10% of your requirements.

    Since it is almost impossible to refuel with liquids, you are better off refuelling with solids and using the liquids to rehydrate.
  • juzb
    Perhaps the citrate's effect as an acid buffer is why it is there? i know there has been research demonstrating that bicarb and citrate can reduce hydrogen ion (acid) accumulation after anaerobic exercise, but I am not sure that it has generalised to improved performance (outside the test tube, that is).
  • sflaherty
    How did cyclists of yesteryear ever cope! (amphetamines I hear you shout)

    Interestingly i visited the dentist recently and was told to stop drinking energy drinks due to the effects of food acid on the teeth. Apparently triathletes have very poor teeth due to high intake of these products.

    I'm going to give the abovementioned product a try. An interesting article but unfortunately I failed Chemistry so i'm playing it safe!
  • mentat6059
    for any weight weenies add a bit more bicarb and use the CO2 produced instead of your gas canisters :)
  • cookie
    Interesting reading. As kevinford stated not much use to an endurance athlete that wants carb replacement also. Any thoughts on tweeking a formulae like this to get the 20g or so of carb per hour? Is it doable?
  • I remember reading a good article once talking about the benefits of ingesting your sugars and your electrolytes separately. Wish I could find it again. I'm pretty sure Joe Friel wrote it.
  • kevinford
    The big issue with any electrolyte only product is its lack of carbs. Drinking this alone will still cause you to go hunger flat and only allow the advertised gains over the short term. In short you must eat as well for a drink like this to be of any use to an endurance athlete. If you look at the make-up of any GOOD electrolyte/carb drink, Endura and TORQ spring to mind, you will find them to be a complete package, negating or lessening the need for adding other things. It is also very important to point out that the dilution rate is absolutely critical for any product of this nature to work effectively as it needs to match our own bodies fluid for osmosis to work. 6% is perfect and no more than 9%. More is not always better
  • Mark_Kelly
    Short answer = No.

    Long answer = Tooth enamel erosion occurs when the pH of the saliva falls to a level where the free H+ ions start replacing the calcium in the enamel, this occurs at pHs below about 5.5 and gets worse as the pH drops. Because of the presence of the sodium the pH of the solution is around 7, because citrate is a tricarboxylic acid it acts as a buffer to reduce the effect of pH changes from other acids (such as those formed by the action of salivary bacteria on sugar solutions). The fluid would therefore have the opposite of the effect you emntion, it should be effective in reducing tooth decay which might otherwise occur.

    BTW I was (briefly) a lab rat at the Institute of Dental Reasearch, we worked on the effect of cation concentration on caries.
  • PommyLee
    Wouldn't the combination of salt and citric acid be really corrosive on your teeth?
  • travis
    it may whiten them.
  • Mark_Kelly
    I found a mistake in my calculations which Wade is going to correct for me.

    In the process of double checking that this time I had it right, I rmade up some new fluid and tried a couple of variations. The original formulation uses tri-sodium citrate which gives a slightly flat soapy taste. I preferred the version with an extra 2.5 g/l citric acid in it which brings it back to something with a little acidity. This only adds about 13mM so it is in the optimal osmotic range (285 - 300mM).
  • Tim
    Mark,
    great stuff.

    Can you advise on the suitability on the replacements below, particularly any changes to quantities.

    - Grey Celtic Sea Salt instead of straight NaCl - the 82 (84?) minerals, do they upset osmotic balance.
    - Stevia instead of Equal/equivalent

    Otherwise, great stuff. I will check out the Hydralyte too.
  • Mark_Kelly
    No problems, but I can't see the benefits either, unless you are phenylketonuric.

    Almost all the salt sold in Australia is sea salt (if you ride near Geelong you've probably seen the mountains of the stuff at Cheetham's, just south of the city). I find it very amusing when people claim there is a significant difference between fancy expensive salt and ordinary salt, given they both came from the same place.

    As for Stelvia, I'm not a toxicologist but it appears to me that Stelvia and Aspartame are both reasonably safe (as stated, except for phenylketonurics). Another source of amusement is the idea that if it's a plant extract it must be good for you. My standard retort is "cocaine".
  • Shaka
    Bets thing available in Aus is Hydralyte - you get it at pharmacies - it's the only local manufacturer with TPG approval.
  • kylieonwheels
    For us noobs...what's TPG approval?
  • travis
    Kylieonwheels TPG is the Therapeutic Good Association (TGA) they are the crowd that tell us that what we are buying is exactly as advertised (ingredients and amounts) as well as telling us that it is ok to use and 'Wont Hurt Us'.
  • yes, but will it work for astronauts and PROs like us?
  • JC
    Bike riders sure are a peculiar breed. We'll pay top retail mark up for bikes, kits, power meters etc etc but insist on making our own gatorade to save a $5????
  • dbelaga
    I have to agree with JC's assessment! There is a large degree of inconsistency, but as the maker of The Right Stuff, I might be a little biased.
  • ambrose
    thats how we can afford all our expensive stuff
  • kylieonwheels
    A CT cooking segment, nice one.

    I have to say, I'm not that into artificial sweeteners. When Mark says you can't add sugar, does that only refer to cane sugar as we know it, or would any type of glucose/sucrose/fructose/etc be ruled out? (eg. a shot of juice or honey). Or, if adding sugars disturbs the balance, is there a balance that can be found with sugars? I mean, you can add some sugar but only if you increase one of the other ingredients?

    Sorry CT, I realise these aren't questions you will have instant answers to, but maybe your friend reads this blog or you might get a list of readers questions for him. Thanks!
  • mikesaif
    I use the natural sweetner from the Stevia plant. It comes in those small packets like the cancer causing poisonous artificial sweetners.
  • kylieonwheels
    Hmm that's interesting too. Where do you get that? Here's some reading I just did. Seems that like everything, the USA got in the way of objective testing, and there's a bit of controversy surrounding Stevia use too. It's so hard to know what to think!

    http://www.organicfooddirectory.com.au/organic-...
    http://en.wikipedia.org/wiki/Stevia
    http://www.stevia.net/
  • mikesaif
    The large corporations that produce sugar and the artificial sweeteners
    managed to lobby and get Stevia banned as a "sweetener" in the U.S. It
    could still be bought as a "supplement" but not marketed as a sweetener.
    This isn't so anymore though. Companies are now selling Stevia as a
    sweetener.

    Try these or search yourself.

    http://www.medicinenet.com/script/main/art.asp?...
    http://www.sciencedaily.com/releases/2006/02/06...
    http://www.cancer.gov/cancertopics/factsheet/Ri...

    Mike Saif
    www.worldclasscoaching.com
    www.finesoccer.com

    WE HAVE MOVED - New Address is - 3404 W. 122nd Terr, Leawood, KS 66209
  • Good question Kylie. I wonder the same. I was looking through the ingredients on Endura last night and noticed that they use artificial sweetener. I assume it's because of the same imbalance reason in the article.

    Mark???!!! Help!
  • Mark_Kelly
    Kylie

    Increasing the concentration of anything which affects osmotic balance will reduce the effectiveness of the fluid : it will become hypertonic. The reason for using artificial sweeteners is that they are effective at very small concentrations which do not affect osmotic balance.

    You can't go the other way either: the researchers tested hypotonic solutions and found them to be less effective.

    I realise I'm bandying the terms hypotonic, hypertonic and osmotic about without expalining them but I've assumed Wade doen't want me to turn his blog into a lecture theatre.
  • kylieonwheels
    Hey no worries, Mark. As a geek I'm actually somewhat excited (note I try not to say 'aroused') by all this sciency talk.

    But yes, in the interest of not turning CT into a science class, might be best to leave it at that. Can you recommend any good online references to learn more about the science of hydration? I'm studying sports nutrition at the moment and I think this would be a good supplement (get it? ha!) to my other study. Cheers!
  • You guys can talk about anything you wish. I don't mind at all if it becomes a science lecture. It's YOUR forum!
  • dbelaga
    I appreciate Mark and W doing a nice job of opening the discussion about The Right Stuff. Mark has done a fair and impartial explanation about the ingredients, including why the patent requires that there are no sugars or carbs. For the complete information about the science behind the formula and to learn about what other users are experiencing please visit our website TheRightStuff-USA.com and our Facebook Fan Page http://tiny.cc/MjAB7

    One other relevant piece of information for cyclists - The Right Stuff is a liquid concentrate, drink additive, available in convenient-to-carry (16.5ml) recyclable plastic vials. So, for those of you that don’t want to take the time to get the ingredients and pull it all together yourself, please feel free to buy the finished product online at our website.
    Thank you all for your thoughts.
    Sincerely,

    David Belaga
    President/CEO
    Wellness Brands Inc.
    Boulder, CO 80301
    Makers of The Right Stuff
  • Pugno
    Do you have anyone selling it in Australia? Preferably in Melb, home of Mr CT haha.
  • dbelaga
    Pugno,
    Thank you for your interest in purchasing The Right Stuff. Unfortunately, we have not yet set up a distributor in Australia, but we are working on it. We are also working on adding the capability of shipping directly to consumers in Australia, so "stay tuned." Once again, to stay up on the latest please visit our website TheRightStuff-USA.com and our Facebook Fan Page http://tiny.cc/MjAB7
  • GFCdomestique
    Time to break out the white coat and test tubes
  • Pugno
    Great Post
  • Nice, thanks or sharing
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